|
rs861539
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
XRCC3 Thr241Met and TYMS variable number tandem repeat polymorphisms are associated with time-to-metastasis in colorectal cancer.
|
29394274 |
2018 |
|
rs750248338
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
XRCC3 Thr241Met and TYMS variable number tandem repeat polymorphisms are associated with time-to-metastasis in colorectal cancer.
|
29394274 |
2018 |
|
rs2296147
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
XPG rs2296147 polymorphism could be predictive of unfavorable prognosis of CRC patients.
|
26887052 |
2016 |
|
rs3783550
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
With stratified analysis, the recessive models of rs3783550 (OR = 2.17, 95% CI: 1.03-4.60, p = 0.043), rs2856838 (OR = 2.58, 95% CI: 1.13-5.87, p = 0.024), rs1609682 (OR = 2.20, 95% CI: 1.04-4.65, p = 0.040), and rs3783521 (OR = 2.13, 95% CI: 1.01-4.49, p = 0.048) revealed significant relationships between these variants and an increased CRC risk only in females.
|
30819119 |
2019 |
|
rs70991108
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
With regard to genotype analysis, we showed the involvement of the DHFR polymorphism (rs70991108) in SEPT9 promoter methylation level in CRC patients only.
|
26633373 |
2015 |
|
rs1805192
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
With adjustment for CRC risk factors, subjects with one or two copies of the G allele of the PPARgamma2 Pro12Ala polymorphism showed a statistically significant reduction in risk compared to those with the CC genotype [odds ratio (OR)=0.53, 95% confidence interval (CI)=0.30-0.92].
|
16513680 |
2006 |
|
rs1801282
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
With adjustment for CRC risk factors, subjects with one or two copies of the G allele of the PPARgamma2 Pro12Ala polymorphism showed a statistically significant reduction in risk compared to those with the CC genotype [odds ratio (OR)=0.53, 95% confidence interval (CI)=0.30-0.92].
|
16513680 |
2006 |
|
rs2241766
|
|
Colorectal Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
With a hospital-based case-control study of 341 cases and 727 controls, the associations between the common variants on ADIPOQ (rs266729, rs822395, rs2241766 and rs1501299) and ADIPOR1 (rs1342387 and rs12733285) and CRC susceptibility were evaluated.
|
25516230 |
2014 |
|
rs822395
|
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
With a hospital-based case-control study of 341 cases and 727 controls, the associations between the common variants on ADIPOQ (rs266729, rs822395, rs2241766 and rs1501299) and ADIPOR1 (rs1342387 and rs12733285) and CRC susceptibility were evaluated.
|
25516230 |
2014 |
|
rs1801166
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
While wild type APC sequences were found in two mummies, we discovered the E1317Q missense mutation, known to be a colorectal cancer predisposing mutation, in a large intestine tissue of an 18th century mummy.
|
26863316 |
2016 |
|
rs1801155
|
|
Colorectal Carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
While the I1307K APC mutation clearly confers an increased lifetime risk for colorectal cancer, there is a paucity of data on the natural history of colonic neoplasia in symptomatic and asymptomatic mutation carriers.
|
15733272 |
2005 |
|
rs1463038513
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
While the I1307K APC mutation clearly confers an increased lifetime risk for colorectal cancer, there is a paucity of data on the natural history of colonic neoplasia in symptomatic and asymptomatic mutation carriers.
|
15733272 |
2005 |
|
rs397507444
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
While the A1298C polymorphism showed no measurable association with the overall risk of colorectal cancer, the 1298CC genotype was associated with a statistically significant increase in the risk when alcohol consumption was high, and was also associated with an approximately 2-fold increase in the risk of each of proximal and distal colon cancer.
|
15546509 |
2004 |
|
rs8105637
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
While for SNP rs8105637, the allele A was significantly associated with 22% increased risk of CRC (OR=1.22; 95% CI=1.09-1.37; P value = 6.2×10-4).
|
28418933 |
2017 |
|
rs3803185
|
|
Colorectal Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Whereas P131L and W149X did not seem to affect CRC risk, C148R did show, for the first time in CRC, statistically significant differences between cases and controls [odds ratio (OR) = 1.45, 95% confidence interval (95% CI) = 1.13-1.86, P = 0.003], sporadic cases and controls (OR = 1.59, 95% CI = 1.13-2.23, P = 0.007) and familial cases and controls (OR = 1.55, 95% CI = 1.10-2.19, P = 0.01) in agreement with a hypothetical moderate increase of the cancer risk linked to the C148R ARLTS1 variant, both in sporadic and familial CRC cases.
|
17449901 |
2007 |
|
rs755100942
|
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Whereas P131L and W149X did not seem to affect CRC risk, C148R did show, for the first time in CRC, statistically significant differences between cases and controls [odds ratio (OR) = 1.45, 95% confidence interval (95% CI) = 1.13-1.86, P = 0.003], sporadic cases and controls (OR = 1.59, 95% CI = 1.13-2.23, P = 0.007) and familial cases and controls (OR = 1.55, 95% CI = 1.10-2.19, P = 0.01) in agreement with a hypothetical moderate increase of the cancer risk linked to the C148R ARLTS1 variant, both in sporadic and familial CRC cases.
|
17449901 |
2007 |
|
rs34301344
|
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Whereas P131L and W149X did not seem to affect CRC risk, C148R did show, for the first time in CRC, statistically significant differences between cases and controls [odds ratio (OR) = 1.45, 95% confidence interval (95% CI) = 1.13-1.86, P = 0.003], sporadic cases and controls (OR = 1.59, 95% CI = 1.13-2.23, P = 0.007) and familial cases and controls (OR = 1.55, 95% CI = 1.10-2.19, P = 0.01) in agreement with a hypothetical moderate increase of the cancer risk linked to the C148R ARLTS1 variant, both in sporadic and familial CRC cases.
|
17449901 |
2007 |
|
rs397507444
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Whereas our results do not support an association of high enzyme activity and increased risk of colorectal cancer in general, we can not exclude an association of patients with hereditary disease and the MTHFR 1298A --> C variant.
|
12618331 |
2003 |
|
rs1800562
|
|
Colorectal Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Whereas a recent study reported an increased risk of colorectal cancer associated with any HFE germ line mutation (C282Y or H63D), other investigators have concluded there is no increased risk, or that any increase is dependent on polymorphisms in HFE-interacting genes such as the transferrin receptor (TFR).
|
15941956 |
2005 |
|
rs147120792
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Whereas P131L and W149X did not seem to affect CRC risk, C148R did show, for the first time in CRC, statistically significant differences between cases and controls [odds ratio (OR) = 1.45, 95% confidence interval (95% CI) = 1.13-1.86, P = 0.003], sporadic cases and controls (OR = 1.59, 95% CI = 1.13-2.23, P = 0.007) and familial cases and controls (OR = 1.55, 95% CI = 1.10-2.19, P = 0.01) in agreement with a hypothetical moderate increase of the cancer risk linked to the C148R ARLTS1 variant, both in sporadic and familial CRC cases.
|
17449901 |
2007 |
|
rs4588
|
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
When subgroup analysis was performed according to sex and age at diagnosis, the study found that the minor- allele genotypes of rs7041 (TG/GG) were significantly associated with colorectal cancer in patients whose age at diagnosis was more than 60 years (OR 1.67, 95%CI 1.06-2.61) and the minor-allele genotypes of rs4588 (CA/AA) were significantly associated with colorectal cancer in males aged 60 years or less (OR 2.34, 95%CI 1.25-4.37).
|
25921141 |
2015 |
|
rs7041
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
When subgroup analysis was performed according to sex and age at diagnosis, the study found that the minor- allele genotypes of rs7041 (TG/GG) were significantly associated with colorectal cancer in patients whose age at diagnosis was more than 60 years (OR 1.67, 95%CI 1.06-2.61) and the minor-allele genotypes of rs4588 (CA/AA) were significantly associated with colorectal cancer in males aged 60 years or less (OR 2.34, 95%CI 1.25-4.37).
|
25921141 |
2015 |
|
rs113488022
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
When subclassified by combined BRAF V600E mutation and MMR status, loss of ARID1A expression was found most commonly in CRCs with the BRAF V600E mutated, MMR- deficient phenotype (58 of 232 cases, 25%, P < .01).
|
24925223 |
2014 |
|
rs121913377
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
When subclassified by combined BRAF V600E mutation and MMR status, loss of ARID1A expression was found most commonly in CRCs with the BRAF V600E mutated, MMR- deficient phenotype (58 of 232 cases, 25%, P < .01).
|
24925223 |
2014 |
|
rs12953717
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
When stratifying for race, the data showed that the rs12953717</span> was associated with a significantly increased CRC risk under all genetic models in Caucasians.
|
23949881 |
2014 |